Research within the CCTPR encompasses a bench to chairside approach by clinician-scientist with a strong foundation in periodontics and basic science research. Clinically impactful and translational research is promoted by the close approximation of the periodontal clinic and basic science research laboratories within the School of Dental Medicine. Further support of the cutting-edge research is provided by the biomedical research infrastructure of the University of Pittsburgh.
Clinical Research
- Randomized control clinical trial comparing surgical treatment modalities for periimplantitis
Investigator: Ravida - Evaluation of experimental peri-implant mucositis
Investigator: Ravida - Prospective evaluation of bleeding on probing as an indicator of peri-implant disease progression
Investigator: Ravida
Translational Research 
- Developing biodegradable metals for load bearing bone fixation devices
Investigator: Sfeir - Local peptide and molecular agent delivery for modulation of the immune response for the treatment of periodontal and peri-implant disease
Investigator: Sfeir - Serum and salivary biomarkers for disease progression and diagnosis
Investigator: Clark - Harnessing Wnt signaling for periodontal regeneration
Investigator: Intini - Oral microbiome and mycobiome colonization on titanium and peek dental implant materials and associated host immune response
Investigator: Bertolini - Biomaterial engineering dental implant titanium surfaces to reduce polymicrobial biofilms and improve osseointegration
Investigator: Bertolini
Basic Science Research 
- Skeletal stem cell localization and function in bone and periodontal regeneration
Investigator: Intini - Characterization of the immune cell repertoire during bone regeneration
Investigator: Clark - Identifying age-related cellular and molecular perturbations in the pathogenesis of periodontal disease and chronic inflammation
Investigator: Clark - Proteomic Profile and Protein-Mediated Biological Processes on teeth and titanium surfaces as modulators of biofilm formation
Investigator: Bertolini